Screening for Presenilin Inhibitors Using the Free-Living Nematode, Caenorhabditis elegans
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چکیده
منابع مشابه
Novel expression of Haemonchus contortus vaccine candidate aminopeptidase H11 using the free-living nematode Caenorhabditis elegans
With the problem of parasitic nematode drug resistance increasing, vaccine development offers an alternative sustainable control approach. For some parasitic nematodes, native extracts enriched for specific proteins are highly protective. However, recombinant forms of these proteins have failed to replicate this protection. This is thought to be due to differences in glycosylation and/or confor...
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S-Adenosylmethionine decarboxylase (SAMDC) is a major regulatory enzyme in the polyamine biosynthesis and is considered a potentially important drug target for the chemotherapy of proliferative and parasitic diseases. To study regulatory mechanisms which are involved in the expression of SAMDC of the free-living nematode Caenorhabditis elegans, we have isolated the SAMDC gene and cDNA. Genomic ...
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Ornithine decarboxylase has been identified and characterized in the free-living nematode Caenorhabditis elegans. Unlike previously described ornithine decarboxylases, the enzyme activity is membrane-associated and remains in the membrane fraction after treatment with high salt, detergents or phosphatidylinositol-specific phospholipase C. Ornithine has an apparent Km value of 2.7 microM for orn...
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The senescent decline that leads inevitably to death in most animal species is accompanied by a massive increase in molecular damage. Yet, the chain of events that initially causes this process, and the determinants of the rate at which it happens, remain poorly understood. For many years, much research on this topic has been guided by an interrelated set of theories that view oxidative damage ...
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ژورنال
عنوان ژورنال: Journal of Biomolecular Screening
سال: 2004
ISSN: 1087-0571,1552-454X
DOI: 10.1177/1087057103261038